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Article Reference Are airways structural abnormalities more frequent in children with recurrent lower respiratory tract infections?
We report bronchoscopic changes observed in children with recurrent lower airways infections (RLAI) and findings in control children undergoing bronchoscopy ...
Article Reference Haemophilus influenzae: recent advances in the understanding of molecular pathogenesis and polymicrobial infections.
Non-typeable Haemophilus influenzae (NTHi) is a human-specific mucosal pathogen and one of the most common causes of bacterial infections in children and ...
Article Reference Non-typeable Haemophilus influenzae, an under-recognised pathogen.
Non-typeable Haemophilus influenzae (NTHi) is a major cause of mucosal infections such as otitis media, sinusitis, conjunctivitis, and exacerbations of chronic ...
Article Reference Lower airway colonization and inflammatory response in COPD: a focus on Haemophilus influenzae.
Bacterial infection of the lower respiratory tract in chronic obstructive pulmonary disease (COPD) patients is common both in stable patients and during acute ...
Article Reference Nontypeable Haemophilus influenzae biofilms: role in chronic airway infections.
Like many pathogens inhabiting mucosal surfaces, nontypeable Haemophilus influenzae (NTHi) forms multicellular biofilm communities both in vitro and in various ...
Article Reference Prevalence and genetic diversity of nontypeable haemophilus influenzae in the respiratory tract of infants and primary caregivers.
Nontypeable Haemophilus influenzae (NTHi) causes otitis media, sinusitis, and likely lower respiratory tract infections in children. Colonization, strain ...
Article Reference Expression of urease by Haemophilus influenzae during human respiratory tract infection and role in survival in an acid environment.
Nontypeable Haemophilus influenzae is a common cause of otitis media in children and lower respiratory tract infection in adults with chronic obstructive ...
Article Reference [Nontypeable Haemophilus influenzae (NTHi) epidemiology].
While most systemic pediatric Haemophilus influenzae infections are caused by the type b strain (Hib), nontypeable H. influenzae: (NTHi) has been considered a ...
Article Reference Molecular basis of increased serum resistance among pulmonary isolates of non-typeable Haemophilus influenzae.
Non-typeable Haemophilus influenzae (NTHi), a common commensal of the human pharynx, is also an opportunistic pathogen if it becomes established in the lower ...
Article Reference Mechanisms of bacterial resistance to antibiotics in infections of COPD patients.
A key characteristic of airway inflammation in chronic obstructive pulmonary disease (COPD) is the persistent presence of bacteria in the lower airways. The ...
Article Reference [A prospective cohort study on community children vaccinated with Haemophilus influenzae type b].
To evaluate the epidemiological effect of Haemophilus influenzae type b conjugate vaccine (Hib).
Article Reference Characterization of nontypeable Haemophilus influenzae collected from respiratory infections and invasive disease cases in Manitoba, Canada.
With the introduction of the Haemophilus influenzae serotype b (Hib) vaccine, invasive Hib disease has decreased substantially, but nontypeable H. influenzae ...
Article Reference Microbial interactions in the respiratory tract.
Upper respiratory tract infections are caused by the synergistic and antagonistic interactions between upper respiratory tract viruses and 3 predominant ...
Article Reference Toll-like receptor 9 is not important for host defense against Haemophilus influenzae.
Non-typeable Haemophilus influenzae (NTHi) is a common Gram-negative respiratory pathogen. We demonstrated previously that myeloid differentiation ...
Article Reference Respiratory syncytial virus-induced dysregulation of expression of a mucosal beta-defensin augments colonization of the upper airway by non-typeable Haemophilus influenzae.
Otitis media (OM) is a polymicrobial disease wherein upper respiratory tract viruses compromise host airway defences, which allows bacterial flora of the ...
Article Reference Cytotoxic T lymphocyte and natural killer cell responses to non-typeable Haemophilus influenzae.
Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells have a key role in host defence against infectious pathogens, but their response to bacteria is not ...
Article Reference Comparative efficacies of different antibiotic treatments to eradicate nontypeable Haemophilus influenzae infection.
Nonencapsulated and nontypeable Haemophilus influenzae (NTHi) is a major cause of human respiratory tract infections. Some strains of NTHi can cause invasive ...
Article Reference Nontypeable Haemophilus influenzae: understanding virulence and commensal behavior.
Haemophilus influenzae is genetically diverse and exists as a near-ubiquitous human commensal or as a pathogen. Invasive type b disease has been almost ...
Article Reference [PCR-based capsular typing of Haemophilus influenzae isolates non-typeable by agglutination].
Haemophilus influenzae is recognized as a pathogenic agent responsible of localized and systemic infections. Six antigenically different capsular ...
Article Reference Safety and efficacy of nasal application of CpG oligodeoxynucleotide as a mucosal adjuvant.
Nasal vaccination is an effective regimen to prevent upper respiratory infections. An appropriate adjuvant is required for the development of a nasal vaccine. ...
Article Reference Role of nontypeable Haemophilus influenzae in exacerbations and progression of chronic obstructive pulmonary disease.
Nontypeable Haemophilus influenzae is the most common bacterial pathogen associated with airway infection in chronic obstructive pulmonary disease, both in ...
Article Reference Vaccine development for non-typeable Haemophilus influenzae and Moraxella catarrhalis: progress and challenges.
An urgent need exists for vaccines to prevent infections caused by nontypeable Haemophilus influenzae and Moraxella catarrhalis. These bacteria cause otitis ...
Article Reference Expression of a peroxiredoxin-glutaredoxin by Haemophilus influenzae in biofilms and during human respiratory tract infection.
Evidence is mounting that nontypeable Haemophilus influenzae grows as a biofilm in the middle ear of children with otitis media and the airways of adults with ...
Article Reference Mucosal immunization against respiratory bacterial pathogens.
Bacterial respiratory diseases remain a major cause of morbidity and mortality throughout the world. The young and the elderly are particularly susceptible to ...
Article Reference Sialylation of lipooligosaccharides promotes biofilm formation by nontypeable Haemophilus influenzae.
Nontypeable Haemophilus influenzae (NTHi) is a major cause of opportunistic respiratory tract infections, including otitis media and bronchitis. The ...
Article Reference High rates of recombination in otitis media isolates of non-typeable Haemophilus influenzae.
Non-typeable (NT) or capsule-deficient, Haemophilus influenzae (Hi) is a common commensal of the upper respiratory tract of humans and can be pathogenic ...
Article Reference Infectious exacerbations of chronic obstructive pulmonary disease associated with respiratory viruses and non-typeable Haemophilus influenzae.
Infectious exacerbations of chronic obstructive pulmonary disease (COPD) have been reported to occur with both viral and bacterial pathogens. In this study, 35 ...
Article Reference Respiratory infections caused by non-typeable Haemophilus influenzae.
This review will consider recent developments in the clinical aspects of infections due to non-typeable Haemophilus influenzae. In addition, newer developments ...
Article Reference Quantitative detection of Moraxella catarrhalis in nasopharyngeal secretions by real-time PCR.
The recognition of Moraxella catarrhalis as an important cause of respiratory tract infections has been protracted, mainly because it is a frequent commensal ...
Article Reference Exploitation of host epithelial signaling networks by respiratory bacterial pathogens.
Although tremendous effort has been put towards identifying the surface molecules of nontypeable Haemophilus influenzae (NTHi) for vaccine development over the ...