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Article Reference Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation.
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. COPD exacerbation, or episodic worsening of symptoms, often results in ...
Article Reference IL-1 receptor regulates microRNA-135b expression in a negative feedback mechanism during cigarette smoke-induced inflammation.
Although microRNA-135b (miR-135b) is known to be associated with cancer, with recent work showing that it is massively induced in the pulmonary tissues of mice ...
Article Reference [Regulation of expression, function, and inflammatory responses of innate immune receptor Toll-like receptor-2 (TLR2) during inflammatory responses against infection].
Toll-like receptor-2 (TLR2) is one of the important innate immune receptors that play an important role in recognizing the pathogens and producing inflammatory ...
Article Reference EVI1 acts as an inducible negative-feedback regulator of NF-κB by inhibiting p65 acetylation.
Inflammation is a hallmark of many important human diseases. Appropriate inflammation is critical for host defense; however, an overactive response is ...
Article Reference Antiinflammatory role of MUC1 mucin during infection with nontypeable Haemophilus influenzae.
MUC1 (or Muc1 in nonhuman species) is a membrane-tethered mucin expressed on the apical surface of mucosal epithelia (including those of the airways) that ...
Article Reference Activation of epidermal growth factor receptor is required for NTHi-induced NF-κB-dependent inflammation.
Inflammation is a hallmark of many serious human diseases. Nontypeable Haemophilus influenzae (NTHi) is an important human pathogen causing respiratory tract ...
Article Reference Peptidylarginine deiminases present in the airways during tobacco smoking and inflammation can citrullinate the host defense peptide LL-37, resulting in altered activities.
Bacterial colonization of the lower respiratory tract is frequently seen in chronic obstructive pulmonary disease (COPD), and may cause exacerbations leading ...
Article Reference Murine model of chronic respiratory inflammation.
The respiratory mucosa is exposed to the external environment each time we breathe and therefore requires a robust and sophisticated immune defense system. As ...
Article Reference Effects of bacterial infection on airway antimicrobial peptides and proteins in COPD.
Pathogenic bacteria colonize the airways of 30% to 40% of patients with COPD and cause approximately 50% of exacerbations. New strains of nontypeable ...
Article Reference Nrf2 regulates chronic lung inflammation and B-cell responses to nontypeable Haemophilus influenzae.
Nrf2 is a leucine zipper transcription factor that protects against oxidant-induced injury. Nontypeable Haemophilus influenzae is responsible for frequent ...
Article Reference Mechanisms of bacterial resistance to antibiotics in infections of COPD patients.
A key characteristic of airway inflammation in chronic obstructive pulmonary disease (COPD) is the persistent presence of bacteria in the lower airways. The ...
Article Reference Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice.
Recent studies have demonstrated that K-ras mutations in lung epithelial cells elicit inflammation that promotes carcinogenesis in mice (intrinsic ...
Article Reference Bacteria challenge in smoke-exposed mice exacerbates inflammation and skews the inflammatory profile.
The pathogenesis of chronic obstructive pulmonary disease is associated with acute episodes of bacterial exacerbations. The most commonly isolated bacteria ...
Article Reference [The role of p38 mitogen activated protein kinase in the inflammatory response of human monocytes infected with nontypeable Haemophilus influenzae].
To investigate the role of mitogen activated protein kinase (MAPK) pathway in the inflammatory response induced by nontypeable Haemophilus influenzae (NTHi).
Article Reference Tympanic membrane changes in experimental acute otitis media and myringotomy.
The present experimental study explored pathomorphological changes and calcium depositions in the tympanic membrane during experimental acute otitis media ...
Article Reference Haemophilus influenzae lysate induces aspects of the chronic obstructive pulmonary disease phenotype.
Nontypeable Haemophilus influenzae (NTHi) commonly colonizes the lower airways of patients with chronic obstructive pulmonary disease (COPD). Whether it ...
Article Reference Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice.
Non-typeable Haemophilus influenza (NTHi) is an important human pathogen causing respiratory tract infections in both adults and children. NTHi infections are ...
Article Reference Nontypeable Haemophilus influenzae: understanding virulence and commensal behavior.
Haemophilus influenzae is genetically diverse and exists as a near-ubiquitous human commensal or as a pathogen. Invasive type b disease has been almost ...
Article Reference Synergistic activation of NF-kappaB by nontypeable H. influenzae and S. pneumoniae is mediated by CK2, IKKbeta-IkappaBalpha, and p38 MAPK.
In review of the past studies on NF-kappaB regulation, most of them have focused on investigating how NF-kappaB is activated by a single inducer at a time. ...
Article Reference The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung.
TLRs are important for the recognition of conserved motifs expressed by invading bacteria. TLR4 is the signaling receptor for LPS, the major proinflammatory ...
Article Reference NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway.
The transcription factor NF-kappaB regulates genes involved in inflammatory and immune responses, tumorigenesis, and apoptosis. In contrast to the pleiotropic ...
Article Reference Nontypeable Haemophilus influenzae activates human eosinophils through beta-glucan receptors.
Eosinophils are a characteristic component of the inflammatory response seen in several diseases, including allergic asthma and chronic obstructive pulmonary ...
Article Reference Programmed inflammatory processes induced by mucosal immunisation.
Inflammation is essential to repair tissue damaged by physical, microbial or allergic mechanisms. Inappropriately zealous responses lead to destructive ...
Article Reference Airway inflammation and etiology of acute exacerbations of chronic bronchitis.
The etiologic role of bacterial pathogens isolated from sputum culture in 40 to 50% of acute exacerbations of chronic bronchitis (AECB) is controversial. If ...
Article Reference Characteristics of the immunological response in the clearance of non-typeable Haemophilus influenzae from the lung.
Clearance of non-typeable Haemophilus influenzae (NTHi) from the respiratory tract was investigated, over time, in immune and non-immune rats. A triphasic ...
Article Reference A possible role for lysozyme in determining acute exacerbation in chronic bronchitis.
The aggregation of non-serotypable Haemophilus influenzae (NTHI) by whole saliva from patients with chronic obstructive lung disease (COLD) was investigated. ...
Article Reference The host immune response contributes to Haemophilus influenzae virulence.
There is compelling evidence that infections with non-typeable Haemophilus influenzae (NTHi) are associated with exacerbations in COPD patients. However, NTHi ...
Article Reference Understanding nontypeable Haemophilus influenzae and chronic obstructive pulmonary disease.
Bacteria are frequently implicated in acute exacerbations of chronic obstructive pulmonary disease (COPD), but their influence on airway inflammation remains ...
Article Reference Cigarette smoke primes the pulmonary environment to IL-1α/CXCR-2-dependent nontypeable Haemophilus influenzae-exacerbated neutrophilia in mice.
Cigarette smoke has a broad impact on the mucosal environment with the ability to alter host defense mechanisms. Within the context of a bacterial infection, ...