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Article Reference A prospective, observational, epidemiological evaluation of the aetiology and antimicrobial susceptibility of acute otitis media in Saudi children younger than 5years of age.
Information regarding acute otitis media (AOM) aetiology is important for developing effective vaccines. Here, bacterial aetiology and antimicrobial ...
Article Reference Non typable-Haemophilus influenzae biofilm formation and acute otitis media.
Non-typable Haemophilus influenzae (NT-Hi) infection is frequently associated with acute otitis media (AOM) treatment failure, recurrence or chronic otitis ...
Article Reference Acute otitis media otopathogens during 2008 to 2010 in Rochester, New York.
The otopathogen distribution colonizing the nasopharynx (NP) and causing acute otitis media (AOM) is in flux following the introduction of pneumococcal ...
Article Reference Epidemiological and microbiological characteristics of culture-proven acute otitis media in Taiwanese children.
Acute otitis media (AOM) is one of the most common diseases in children. Here, we describe the epidemiological and microbiological characteristics of AOM in ...
Article Reference Correlation of nasopharyngeal cultures prior to and at onset of acute otitis media with middle ear fluid cultures.
We sought to determine if nasopharyngeal (NP) cultures taken at times of healthy visits or at onset of acute otitis media (AOM) could predict the otopathogen ...
Article Reference Differential impact of respiratory syncytial virus and parainfluenza virus on the frequency of acute otitis media is explained by lower adaptive and innate immune responses in otitis-prone children.
Acute otitis media (AOM) is a leading cause of bacterial pediatric infections associated with viral upper respiratory infections (URIs). We examined the ...
Article Reference Transcriptome signature in young children with acute otitis media due to non-typeable Haemophilus influenzae.
Non-typeable Haemophilus influenzae (NTHi) causes acute otitis media (AOM) in young children. In our recent paper in Microbes and Infection we described the ...
Article Reference Higher serum levels of interleukin 10 occur at onset of acute otitis media caused by Streptococcus pneumoniae compared to Haemophilus influenzae and Moraxella catarrhalis.
Acute otitis media (AOM) involves an inflammatory response to microbes in the middle ear that facilitates clearance of otopathogens. Clinically, Streptococcus ...
Article Reference Cellular immune response in young children accounts for recurrent acute otitis media.
Acute otitis media (AOM) is a common disease in young children. Streptococcus pneumoniae (Spn) and Haemophilus influenzae (NTHi) are the two most common ...
Article Reference Bactericidal antibody response against P6, protein D, and OMP26 of nontypeable Haemophilus influenzae after acute otitis media in otitis-prone children.
The bactericidal antibody response to three nontypeable Haemophilus influenzae (NTHi) outer membrane proteins (D, P6, and OMP26) was studied in 24 otitis-prone ...
Article Reference Current management of pediatric acute otitis media.
Acute otitis media (AOM) is the most common childhood bacterial infection for which antibiotics are prescribed worldwide. The most common pathogens causing AOM ...
Article Reference Recent advances in otitis media.
Otitis media (OM) is a pervasive illness in infants and children, and many children suffer multiple episodes during the first years of life. High rates of ...
Article Reference New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine.
To describe NP and AOM otopathogens during the time frame 2007 to 2009, 6 to 8 years after the introduction of 7-valent pneumococcal conjugate (PCV7) in the ...
Article Reference The role of Toll-like receptor 4 in eliciting acquired immune responses against nontypeable Haemophilus influenzae following intranasal immunization with outer membrane protein.
Acute otitis media (AOM) is one of the most common infectious diseases in children. Nontypeable Haemophilus influenzae (NTHi) is considered a major pathogen in ...
Article Reference Nontypeable Haemophilus influenzae isolated from intractable acute otitis media internalized into cultured human epithelial cells.
The aim of this study is to examine the internalization of nontypeable Haemophilus influenzae (NTHi) into human epithelial cells.
Article Reference Potential contribution by nontypable Haemophilus influenzae in protracted and recurrent acute otitis media.
Characterization of acute otitis media (AOM) caused by nontypable Haemophilus influenzae (NTHi) is important, particularly in view of the efforts to develop ...
Article Reference Survival of bacterial biofilms within neutrophil extracellular traps promotes nontypeable Haemophilus influenzae persistence in the chinchilla model for otitis media.
Nontypeable Haemophilus influenzae (NTHi) is a leading cause of acute and chronic otitis media, which are a major public health problem worldwide. The ...
Article Reference Differential expression of cytokine genes and iNOS induced by nonviable nontypeable Haemophilus influenzae or its LOS mutants during acute otitis media in the rat.
We have previously demonstrated that the disruptions of nontypeable Haemophilus influenzae (NTHi) lipooligosaccharide (LOS) htrB and rfaD genes may play a role ...
Article Reference Tympanic membrane changes in experimental acute otitis media and myringotomy.
The present experimental study explored pathomorphological changes and calcium depositions in the tympanic membrane during experimental acute otitis media ...
Article Reference Genetic diversity of paired middle-ear and pharyngeal nontypeable Haemophilus influenzae isolates from children with acute otitis media.
Pulsed-field gel electrophoresis was used to determine genetic diversities of multiple nontypeable Haemophilus influenzae isolates from throat and ear ...
Article Reference Is bilateral acute otitis media clinically different than unilateral acute otitis media?
Information regarding the specific characteristics of bilateral acute otitis media (BAOM) versus unilateral acute otitis media (UAOM) is lacking.
Article Reference Toll-like receptor 2-dependent NF-kappaB activation is involved in nontypeable Haemophilus influenzae-induced monocyte chemotactic protein 1 up-regulation in the spiral ligament fibrocytes of the inner ear.
Inner ear dysfunction secondary to chronic otitis media (OM), including high-frequency sensorineural hearing loss or vertigo, is not uncommon. Although chronic ...
Article Reference Oral beta-lactams in the treatment of acute otitis media.
Acute otitis media (AOM) is an important infectious disease among children throughout the world. The management of AOM is complicated by difficulties in ...
Article Reference Role of Toll-like receptor 4 in innate immune responses in a mouse model of acute otitis media.
Nontypeable Haemophilus influenzae (NTHi) is considered a major pathogen underlying middle ear infection. This study characterized the role of Toll-like ...
Article Reference Mathematical model comparisons of potential non-typeable Haemophilus influenzae vaccine effects.
Vaccines to prevent acute otitis media (AOM) caused by non-typeable Haemophilus influenzae (NTHi) are under development. Because NTHi is highly variable and ...
Article Reference Otomicroscopic findings and systemic interleukin-6 levels in relation to etiologic agent during experimental acute otitis media.
The aim of the present study was to explore whether it was possible to differentiate the clinical course and the otomicroscopic appearance of acute otitis ...
Article Reference Kinetic Th1/Th2 responses of transgenic mice with bacterial meningitis induced by Haemophilus influenzae.
To investigate the kinetic Th1/Th2 immunopathogenic mechanisms of Haemophilus influenzae meningitis, we established a murine experimental model of meningitis ...
Article Reference Treating acute otitis media post-PCV-7: judicious antibiotic therapy.
Acute otitis media (AOM) is treated with antibiotics in the United States, but the changing distribution of bacterial pathogens that cause the disorder can ...
Article Reference Development of myringosclerosis during acute otitis media caused by Streptococcus pneumoniae and non-typeable Haemophilus influenzae: a clinical otomicroscopical study using the rat model.
The present study was performed in order to study development of myringosclerosis during acute otitis media caused by different bacteria in myringotomized and ...
Article Reference Calcium deposition and expression of bone modelling markers in the tympanic membrane following acute otitis media.
In accordance with clinical findings, myringosclerosis develops after otitis media (OM) and paracentesis in an experimental setting. The pathogenesis of this ...