Timothy F Murphy MD
Senior Associate Dean for Clinical and Translational Research
- Fellowship, Infectious Diseases, Tufts University, Infectious Diseases, 1981
- Residency, Medicine, New York Hospital Cornell Medical Center, Medicine, 1979
- MD, Tufts University, 1976
Respiratory tract bacterial pathogens Vaccine development Bacterial infection in chronic obstructive pulmonary disease Haemophilus influenzae Moraxella catarrhalis Research in my laboratory focuses on nontypeable Haemophilus influenzae and Moraxella catarrhalis, important pathogens in otitis media and lower respiratory tract infections in adults with chronic obstructive pulmonary disease (COPD). A goal of work is to develop vaccine to prevent these infections. To that end, outer membrane proteins have been identified and are being evaluated as potential vaccine antigens. A COPD Study Clinic supported by a grant from the Department of Veteran Affairs has been running continuously since 1994. This prospective study follows adults with COPD during monthly clinic visits during which sputum and serum samples are collected. Bacterial isolates are recovered from sputum and are subjected to molecular typing. These studies are elucidating the dynamics of respiratory tract bacterial colonization. In addition, serum and sputum samples are being studied to learn about systemic and mucosal immune responses to bacterial pathogens.