Lauren O Bakaletz PhD
- Post Doctoral
- The Ohio State University
- Date Completed: 06/30/1984
- Center for Microbial Pathogenesis
Our laboratory’s research focus is attempting to understand the pathogenic mechanisms operational in the polymicrobial disease, otitis media (OM) (or middle ear infection). Specifically, we are interested in elucidating how upper respiratory tract viruses predispose the middle ear to invasion by any of the three predominant bacterial pathogens of OM. We are also interested in understanding how the mammalian host responds to each of these groups of microbes, particularly at the level of innate immunity, as well as determining how the bacteria involved (primarily nontypeable Haemophilus influenzae) defend themselves against these innate immune effectors. Using multiple approaches, we then attempt to identify potential molecular targets for the design, development and pre-clinical testing of vaccine candidates using an animal model of viral-bacterial superinfection that we developed. Our long-term goal is to develop novel methods to treat or preferably, to prevent, otitis media.