You are here: Home Published Research Haemophilus influenzae oral vaccination for preventing acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease.

Edward Teo, Hugh House, Kathleen Lockhart, Sai N Purchuri, Jennifer Pushparajah, Allan W Cripps, and Mieke L van Driel (2014)

Haemophilus influenzae oral vaccination for preventing acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease.

The Cochrane database of systematic reviews, 9(9):CD010010.

Chronic bronchitis and chronic obstructive pulmonary disease (COPD) are serious conditions in which patients are predisposed to viral and bacterial infections resulting in potentially fatal acute exacerbations. COPD is defined as a lung disease characterised by obstruction to lung airflow that interferes with normal breathing. Antibiotic therapy has not been particularly useful in eradicating bacteria such as non-typeable Haemophilus influenzae (NTHi) because they are naturally occurring flora of the upper respiratory tract in many people. However, they can cause opportunistic infection. An oral NTHi vaccine has been developed to protect against recurrent infective acute exacerbations in chronic bronchitis.

Administration, Oral, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Bronchitis, Chronic, Disease Progression, Haemophilus Vaccines, Haemophilus influenzae, Humans, Middle Aged, Pulmonary Disease, Chronic Obstructive, Randomized Controlled Trials as Topic, Secondary Prevention
Administration, Oral, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Bronchitis, Chronic, Disease Progression, Haemophilus Vaccines, Haemophilus influenzae, Humans, Middle Aged, Pulmonary Disease, Chronic Obstructive, Randomized Controlled Trials as Topic, Secondary Prevention
 
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