You are here: Home Published Research Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable Haemophilus influenzae.

Heidi C Smith-Vaughan, Anne B Chang, Derek S Sarovich, Robyn L Marsh, Keith Grimwood, Amanda J Leach, Peter S Morris, and Erin P Price (2014)

Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable Haemophilus influenzae.

Clinical and vaccine immunology : CVI, 21(2):250–252.

Nontypeable Haemophilus influenzae (NTHi)-associated disease is a major health problem globally. Whole-genome sequence analysis identified the absence of hpd genes encoding Haemophilus protein D in 3 of 16 phylogenetically distinct NTHi isolates. This novel finding is of potential clinical significance, as protein D and hpd represent important NTHi vaccine antigen and diagnostic targets, respectively.

Antigens, Bacterial, Carrier State, Child, Child, Preschool, Cluster Analysis, DNA, Bacterial, Female, Gene Deletion, Genes, Bacterial, Global Health, Haemophilus Infections, Haemophilus Vaccines, Haemophilus influenzae, Humans, Infant, Male, Phylogeny
Antigens, Bacterial, Carrier State, Child, Child, Preschool, Cluster Analysis, DNA, Bacterial, Female, Gene Deletion, Genes, Bacterial, Global Health, Haemophilus Infections, Haemophilus Vaccines, Haemophilus influenzae, Humans, Infant, Male, Phylogeny
 
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