You are here: Home Published Research Haemophilus influenzae reside in tonsills and use IgD binding as an evasion strategy.

Kalpana Singh, Therése Nordström, Matthias Mörgelin, Marta Brant, Lars-Olaf Cardell, and Kristian Riesbeck (2013)

Haemophilus influenzae reside in tonsills and use IgD binding as an evasion strategy.

The Journal of infectious diseases.

Haemophilus influenzae (Hi) causes respiratory tract infections and is also considered as a commensal, particularly in pre-school children. Tonsils from patients (n=617) undergoing tonsillectomy due to chronical infection or hypertrophy were examined. We found that 51 % of tonsils were positive for Hi, and in 95 % of cases analysed in detail (n=39) Hi resided intracellularly in the core tonsillar tissue. Patients harboured several intracellular unique strains and the majority were non-typeable Hi (NTHi). Interestingly, the isolated NTHi bound soluble immunoglobulin (Ig) D at the constant heavy chain domain 1 as revealed by recombinant IgD/IgG chimeras. NTHi also interacted with B lymphocytes via the IgD B cell receptor resulting in internalization of bacteria, T-cell independent activation via Toll like receptor 9, and differentiation into non-NTHi specific IgM producing cells. Taken together, IgD-binding NTHi leads to an unspecific immune response and may support the bacteria to circumvent the host defense.

 
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