You are here: Home Published Research PAI-1 inhibits development of chronic otitis media and tympanosclerosis in a mouse model of otitis media.

Seul G Shin, Seo H Koh, Chang-Hoon Woo, and Jae H Lim (2014)

PAI-1 inhibits development of chronic otitis media and tympanosclerosis in a mouse model of otitis media.

Acta oto-laryngologica, 134(12):1231–1238.

Bullae of type 1 plasminogen activator inhibitor (PAI-1) knockout (KO) mice showed low levels of inflammation against nontypable Haemophilus influenzae (NTHi) at the early stage of otitis media (OM). However, PAI-1 KO mice fail to terminate inflammation, which may significantly contribute to the development of tympanosclerosis in PAI-1 KO mice.

Animals, Chronic Disease, Disease Models, Animal, Follow-Up Studies, Gene Expression Regulation, Mice, Mice, Inbred C57BL, Mice, Knockout, Myringosclerosis, Otitis Media, Plasminogen Activator Inhibitor 1, RNA, Reverse Transcriptase Polymerase Chain Reaction
Animals, Chronic Disease, Disease Models, Animal, Follow-Up Studies, Gene Expression Regulation, Mice, Mice, Inbred C57BL, Mice, Knockout, Myringosclerosis, Otitis Media, Plasminogen Activator Inhibitor 1, RNA, Reverse Transcriptase Polymerase Chain Reaction
 
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