You are here: Home Published Research Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae.

Viveka Schaar, Ida Uddbäck, Therese Nordström, and Kristian Riesbeck (2014)

Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae.

The Journal of antimicrobial chemotherapy, 69(1):117–120.

Group A streptococci (GAS) cause, among other infections, pharyngotonsillitis in children. The species is frequently localized with the Gram-negative respiratory pathogens non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis, which both produce outer membrane vesicles (OMVs). The aim of this study was to investigate whether OMVs isolated from NTHi contain functional β-lactamase and whether the OMVs hydrolyse amoxicillin and thus protect GAS from killing by the antibiotic.

Amoxicillin, Anti-Bacterial Agents, Exosomes, Haemophilus influenzae, Hydrolysis, Microbial Sensitivity Tests, Microbial Viability, Streptococcus pyogenes, beta-Lactamases
Amoxicillin, Anti-Bacterial Agents, Exosomes, Haemophilus influenzae, Hydrolysis, Microbial Sensitivity Tests, Microbial Viability, Streptococcus pyogenes, beta-Lactamases
 
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