You are here: Home Published Research Toxin-antitoxin loci vapBC-1 and vapXD contribute to survival and virulence in nontypeable Haemophilus influenzae.

Dabin Ren, Anna N Walker, and Dayle A Daines (2012)

Toxin-antitoxin loci vapBC-1 and vapXD contribute to survival and virulence in nontypeable Haemophilus influenzae.

BMC microbiology, 12(1):263.

Nontypeable Haemophilus influenzae (NTHi) is a significant human pathogen responsible for respiratory tract infections and the most common cause of recurrent otitis media. Type II toxin-antitoxin (TA) systems are genetic elements that code for a stable protein toxin and a labile antitoxin that are thought to be involved in metabolic regulation of bacteria by enabling a switch to a dormant state under stress conditions. The contribution to infection persistence of the NTHi TA loci vapBC-1 and vapXD was examined in this study.

Animals, Bacterial Proteins, Bacterial Toxins, Chinchilla, Disease Models, Animal, Female, Gene Deletion, Haemophilus influenzae, Humans, Microbial Viability, Otitis Media, Protein Multimerization, Respiratory Mucosa, Virulence, Virulence Factors
Animals, Bacterial Proteins, Bacterial Toxins, Chinchilla, Disease Models, Animal, Female, Gene Deletion, Haemophilus influenzae, Humans, Microbial Viability, Otitis Media, Protein Multimerization, Respiratory Mucosa, Virulence, Virulence Factors
 
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