You are here: Home Published Research Impact of the 10-valent pneumococcal non-typeable Haemophilus influenzae Protein D conjugate vaccine (PHiD-CV) on bacterial nasopharyngeal carriage.

Roman Prymula, Irena Hanovcova, Miroslav Splino, Pavla Kriz, Jitka Motlova, Vera Lebedova, Patricia Lommel, Eva Kaliskova, Thierry Pascal, Dorota Borys, and Lode Schuerman (2011)

Impact of the 10-valent pneumococcal non-typeable Haemophilus influenzae Protein D conjugate vaccine (PHiD-CV) on bacterial nasopharyngeal carriage.

Vaccine, 29(10):1959–1967.

Pneumococcal conjugate vaccines (PCV) may reduce nasopharyngeal carriage (NPC) of Streptococcus pneumoniae vaccine strains (VT), but serotype replacement with non-vaccine strains (NVT) has been reported. Bacterial NPC after PHiD-CV vaccination was assessed in the second year of life. Open descriptive study of NPC reported for 414 subjects vaccinated at 3-5 and 12-15 months of age with PHiD-CV with or without prophylactic paracetamol (PP) compared to 336 age-matched PCV-naïve controls. Carriage was assessed prior to and 1, 3, 7 and 12 months after PHiD-CV booster or MenACWY-TT control vaccination at 12-15 months of age. At each visit, carriage of VT was reduced by 22-35% in PHiD-CV recipients. Vaccine efficacy across all visits was 21.7% [95% CI 2.6; 37.0] (26.8% carriage in the PHiD-CV group versus 34.2% in controls). Carriage rates of NVT tended to be higher in PHiD-CV recipients. Pre-booster, these findings were more pronounced when PP had not been administered. No substantial effect of PHiD-CV vaccination was observed on NPC of other bacterial pathogens including non-typeable Haemophilus influenzae. Primary and booster vaccination with PHiD-CV reduced NPC of VT in the second year of life and tended to slightly increase that of NVT in line with previous experience with the 7-valent PCV.

Carrier State, Female, Haemophilus Infections, Haemophilus influenzae, Humans, Immunization, Secondary, Infant, Male, Nasopharynx, Pneumococcal Infections, Pneumococcal Vaccines, Streptococcus pneumoniae, Vaccination
Carrier State, Female, Haemophilus Infections, Haemophilus influenzae, Humans, Immunization, Secondary, Infant, Male, Nasopharynx, Pneumococcal Infections, Pneumococcal Vaccines, Streptococcus pneumoniae, Vaccination
 
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