You are here: Home Published Research NTHi induction of Cxcl2 and middle ear mucosal metaplasia in mice.

Diego Preciado, Katelyn Burgett, Svetlana Ghimbovschi, and Mary Rose (2013)

NTHi induction of Cxcl2 and middle ear mucosal metaplasia in mice.

The Laryngoscope, 123(11):E66–E71.

Chronic otitis media (COM) develops after sustained inflammation and is characterized by secretory middle ear epithelial metaplasia and effusion, most frequently mucoid. Nontypeable Haemophilus influenzae (NTHi), the most common acute otitis media (OM) pathogen, is known to activate inflammation and mucin expression in vitro and in animal models of OM. The goals of this study were to examine histopathological and expression profiling epithelial effects of NTHi challenge in murine middle ears.

Animals, Chemokine CXCL2, Ear, Middle, Haemophilus Infections, Haemophilus influenzae, Metaplasia, Mice, Mice, Inbred BALB C, Mucous Membrane, Otitis Media
Animals, Chemokine CXCL2, Ear, Middle, Haemophilus Infections, Haemophilus influenzae, Metaplasia, Mice, Mice, Inbred BALB C, Mucous Membrane, Otitis Media
 
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