You are here: Home Published Research Improving immunity to Haemophilus influenzae in children with chronic suppurative lung disease.

Susan J Pizzutto, Stephanie T Yerkovich, John W Upham, Belinda J Hales, Wayne R Thomas, and Anne B Chang (2014)

Improving immunity to Haemophilus influenzae in children with chronic suppurative lung disease.

Vaccine.

Endobronchial infections related to non-typeable Haemophilus influenzae (NTHi) are common in children and adults with suppurative airway disease such as bronchiectasis and COPD. Impaired cell mediated immune responses to NTHi have been described in these patients. Currently there are no interventions known to correct the deficiency in cell mediated immune responses to NTHi. The aim of this study was to determine if receipt of a conjugate vaccine containing protein D from H. influenzae is associated with improvement in NTHi-specific cytokine responses in children with chronic suppurative lung disease.

 
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