You are here: Home Published Research Higher serum levels of interleukin 10 occur at onset of acute otitis media caused by Streptococcus pneumoniae compared to Haemophilus influenzae and Moraxella catarrhalis.

Keyi Liu, Ravinder Kaur, Anthony Almudevar, and Michael E Pichichero (2013)

Higher serum levels of interleukin 10 occur at onset of acute otitis media caused by Streptococcus pneumoniae compared to Haemophilus influenzae and Moraxella catarrhalis.

The Laryngoscope, 123(6):1500–1505.

Acute otitis media (AOM) involves an inflammatory response to microbes in the middle ear that facilitates clearance of otopathogens. Clinically, Streptococcus pneumoniae (Spn) infections of the respiratory tract are characterized by greater inflammatory responses than nontypeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat). Interleukin 10 (IL-10) plays an important role in down-regulating the inflammatory response. We compared serum IL-10 levels in children before onset, at onset, and after recovery from AOM caused by Spn, NTHi, and Mcat. We sought to determine if IL-10 could serve as a biomarker to distinguish AOM caused by Spn versus NTHi and Mcat.

Acute Disease, Biological Markers, Child, Preschool, Ear, Middle, Female, Follow-Up Studies, Haemophilus Infections, Haemophilus influenzae, Humans, Infant, Interleukin-10, Male, Moraxella (Branhamella) catarrhalis, Moraxellaceae Infections, Otitis Media, Pneumococcal Infections, Prospective Studies, Severity of Illness Index, Streptococcus pneumoniae
Acute Disease, Biological Markers, Child, Preschool, Ear, Middle, Female, Follow-Up Studies, Haemophilus Infections, Haemophilus influenzae, Humans, Infant, Interleukin-10, Male, Moraxella (Branhamella) catarrhalis, Moraxellaceae Infections, Otitis Media, Pneumococcal Infections, Prospective Studies, Severity of Illness Index, Streptococcus pneumoniae
 
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