You are here: Home Published Research T-regulatory cells and programmed death 1+ T cells contribute to effector T-cell dysfunction in patients with chronic obstructive pulmonary disease.

Suresh G Kalathil, Amit A Lugade, Vandana Pradhan, Austin Miller, Ganapathi I Parameswaran, Sanjay Sethi, and Yasmin Thanavala (2014)

T-regulatory cells and programmed death 1+ T cells contribute to effector T-cell dysfunction in patients with chronic obstructive pulmonary disease.

American journal of respiratory and critical care medicine, 190(1):40–50.

Previous studies from our laboratory have shown that peripheral blood mononuclear cells (PBMCs) from patients with chronic obstructive pulmonary disease (COPD) prone to exacerbations with nontypeable Haemophilus influenzae have impaired responses to lipoprotein P6. We hypothesized that an underlying immunosuppressive network could be responsible for the defective antibacterial immunity observed in these patients. We evaluated T regulatory cells (Tregs), myeloid-derived suppressor cells (MDSC), and exhausted T effector cells (programmed death 1 [PD-1](+)) in patients with COPD, because these cells are known to play a pivotal role in suppressing immune responses.

Aged, Aged, 80 and over, Apoptosis, Case-Control Studies, Cytokines, Disease Progression, Female, Forced Expiratory Volume, Humans, Immune Tolerance, Male, Middle Aged, Myeloid Cells, Pulmonary Disease, Chronic Obstructive, Severity of Illness Index, Smoking, T-Lymphocytes, Regulatory
Aged, Aged, 80 and over, Apoptosis, Case-Control Studies, Cytokines, Disease Progression, Female, Forced Expiratory Volume, Humans, Immune Tolerance, Male, Middle Aged, Myeloid Cells, Pulmonary Disease, Chronic Obstructive, Severity of Illness Index, Smoking, T-Lymphocytes, Regulatory
 
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