You are here: Home Published Research Human neutrophil elastase degrades SPLUNC1 and impairs airway epithelial defense against bacteria.

Di Jiang, Sally E Wenzel, Qun Wu, Russell P Bowler, Christina Schnell, and Hong W Chu (2013)

Human neutrophil elastase degrades SPLUNC1 and impairs airway epithelial defense against bacteria.

PloS one, 8(5):e64689.

Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a significant cause of mortality of COPD patients, and pose a huge burden on healthcare. One of the major causes of AECOPD is airway bacterial (e.g. nontypeable Haemophilus influenzae [NTHi]) infection. However, the mechanisms underlying bacterial infections during AECOPD remain poorly understood. As neutrophilic inflammation including increased release of human neutrophil elastase (HNE) is a salient feature of AECOPD, we hypothesized that HNE impairs airway epithelial defense against NTHi by degrading airway epithelial host defense proteins such as short palate, lung, and nasal epithelium clone 1 (SPLUNC1).

Animals, Cells, Cultured, Epithelial Cells, Glycoproteins, Haemophilus Infections, Haemophilus influenzae, Humans, Leukocyte Elastase, Lung, Mice, Mice, Knockout, Neutrophil Infiltration, Phosphoproteins, Proteolysis, Pulmonary Disease, Chronic Obstructive, Recombinant Proteins, Respiratory Mucosa
Animals, Cells, Cultured, Epithelial Cells, Glycoproteins, Haemophilus Infections, Haemophilus influenzae, Humans, Leukocyte Elastase, Lung, Mice, Mice, Knockout, Neutrophil Infiltration, Phosphoproteins, Proteolysis, Pulmonary Disease, Chronic Obstructive, Recombinant Proteins, Respiratory Mucosa
 
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