You are here: Home Published Research Eotaxin-3 (CCL26) exerts innate host defense activities that are modulated by mast cell proteases.

Anele Gela, Gopinath Kasetty, Sandra Jovic, Maria Ekoff, Gunnar Nilsson, Matthias Mörgelin, Sven Kjellström, James E Pease, Artur Schmidtchen, and Arne Egesten (2014)

Eotaxin-3 (CCL26) exerts innate host defense activities that are modulated by mast cell proteases.

Allergy.

During bacterial infections of the airways, a Th1-profiled inflammation promotes the production of several host defense proteins and peptides with antibacterial activities including β-defensins, ELR-negative CXC-chemokines, and the cathelicidin LL-37. These are down-regulated by Th2 cytokines of the allergic response. Instead, the eosinophil-recruiting chemokines eotaxin-1/CCL11, eotaxin-2/CCL24, and eotaxin-3/CCL26 are expressed. This study set out to investigate if these chemokines could serve as innate host defense molecules during allergic inflammation.

 
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