You are here: Home Published Research The host immune response contributes to Haemophilus influenzae virulence.

Tanja H Geelen, Giel R Gaajetaan, Emiel F Wouters, Gernot G Rohde, Frits M Franssen, Gert E Grauls, Ellen E Stobberingh, Cathrien A Bruggeman, and Frank R Stassen (2014)

The host immune response contributes to Haemophilus influenzae virulence.

Respiratory medicine, 108(1):144–152.

There is compelling evidence that infections with non-typeable Haemophilus influenzae (NTHi) are associated with exacerbations in COPD patients. However, NTHi has also been isolated frequently during clinically stable disease. In this study we tested the hypothesis that genetically distinct NTHi isolates obtained from COPD patients differ in virulence which could account for dissimilarities in the final outcome of an infection (stable vs. exacerbation).

Aged, Body Mass Index, Disease Progression, Female, Haemophilus Infections, Haemophilus influenzae, Host-Pathogen Interactions, Humans, Inflammation, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive, Risk Factors, Smoking
Aged, Body Mass Index, Disease Progression, Female, Haemophilus Infections, Haemophilus influenzae, Host-Pathogen Interactions, Humans, Inflammation, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive, Risk Factors, Smoking
 
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