You are here: Home Published Research Improving patient care via development of a protein-based diagnostic test for microbe-specific detection of chronic rhinosinusitis.

Subinoy Das, Lucia E Rosas, Joseph A Jurcisek, Laura A Novotny, Kari B Green, and Lauren O Bakaletz (2014)

Improving patient care via development of a protein-based diagnostic test for microbe-specific detection of chronic rhinosinusitis.

The Laryngoscope, 124(3):608–615.

The hypothesis is that signature bacterial proteins can be identified in sinus secretions via high-throughput, proteomic based techniques. Nontypeable Haemophilus influenzae (NTHI) is the most common bacterial pathogen associated with sinusitis and serves as proof of principle pathogen for identifying biomarkers.

Animals, Bacterial Outer Membrane Proteins, Bacterial Proteins, Biofilms, Biomarkers, Chinchilla, Chronic Disease, Disease Models, Animal, Haemophilus Infections, Haemophilus influenzae, Humans, In Vitro Techniques, Patient Care, Proteomics, Quality Improvement, Real-Time Polymerase Chain Reaction, Reference Standards, Reproducibility of Results, Rhinitis, Sensitivity and Specificity, Sinusitis, Tandem Mass Spectrometry
Animals, Bacterial Outer Membrane Proteins, Bacterial Proteins, Biofilms, Biomarkers, Chinchilla, Chronic Disease, Disease Models, Animal, Haemophilus Infections, Haemophilus influenzae, Humans, In Vitro Techniques, Patient Care, Proteomics, Quality Improvement, Real-Time Polymerase Chain Reaction, Reference Standards, Reproducibility of Results, Rhinitis, Sensitivity and Specificity, Sinusitis, Tandem Mass Spectrometry
 
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