You are here: Home Published Research Antibodies directed against integration host factor mediate biofilm clearance from Nasopore.

Kathleyn A Brandstetter, Joseph A Jurcisek, Steven D Goodman, Lauren O Bakaletz, and Subinoy Das (2013)

Antibodies directed against integration host factor mediate biofilm clearance from Nasopore.

The Laryngoscope, 123(11):2626–2632.

Intranasal resorbable packing, such as Nasopore, is commonly used during sinus surgery despite a paucity of evidence that demonstrates clinical benefit. We theorized that Nasopore supports bacterial growth and biofilm formation. The DNABII family of bacterial nucleic acid binding proteins stabilizes the extracellular polymeric substance of the biofilm, thus protecting bacteria from host defenses and traditional antibiotics. We tested the hypothesis that use of anti-IHF antibodies in conjunction with antibiotics would enhance biofilm eradication from Nasopore.

Amoxicillin-Potassium Clavulanate Combination, Anti-Bacterial Agents, Antibodies, Biofilms, Haemophilus influenzae, Integration Host Factors, Tampons, Surgical
Amoxicillin-Potassium Clavulanate Combination, Anti-Bacterial Agents, Antibodies, Biofilms, Haemophilus influenzae, Integration Host Factors, Tampons, Surgical
 
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