You are here: Home Published Research Innate immune properties of selected human neuropeptides against Moraxella catarrhalis and nontypeable Haemophilus influenzae.

Daria Augustyniak, Adam Jankowski, PaweĊ‚ Mackiewicz, Agnieszka Skowyra, Jan Gutowicz, and Zuzanna Drulis-Kawa (2012)

Innate immune properties of selected human neuropeptides against Moraxella catarrhalis and nontypeable Haemophilus influenzae.

BMC immunology, 13:24.

Considerable evidence supports the concept of active communication between the nervous and immune systems. One class of such communicators are the neuropeptides (NPs). Recent reports have highlighted the antimicrobial activity of neuropeptides, placing them among the integral components of innate immune defense. This study examined the action of four human neuropeptides: calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), substance P (SP) and somatostatin (SOM), which are accessible in the upper respiratory tract, against two human-specific respiratory pathogens. We studied: (i) neuropeptide-mediated direct antibacterial activity exerted against Moraxella catarrhalis and nontypeable Haemophilus influenzae, and (ii) indirect immunomodulatory role of these neuropeptides in the neutrophil-mediated phagocytosis of indicated pathogens.

Anti-Bacterial Agents, Calcitonin Gene-Related Peptide, Cell Death, Cells, Cultured, Haemophilus Infections, Haemophilus influenzae, Humans, Immunity, Innate, Moraxella (Branhamella) catarrhalis, Moraxellaceae Infections, Neuropeptide Y, Neutrophils, Phagocytosis, Somatostatin, Substance P
Anti-Bacterial Agents, Calcitonin Gene-Related Peptide, Cell Death, Cells, Cultured, Haemophilus Infections, Haemophilus influenzae, Humans, Immunity, Innate, Moraxella (Branhamella) catarrhalis, Moraxellaceae Infections, Neuropeptide Y, Neutrophils, Phagocytosis, Somatostatin, Substance P
 
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